The incidence and risk of cardiovascular events associated with immune checkpoint inhibitors in Asian populations.

ABSTRACT:

Objectives

Immune checkpoint inhibitors are associated with adverse cardiovascular events. However, there are no data characterizing cardiovascular events among Asians on immune checkpoint inhibitors. We aim to determine the incidence and risk of cardiac events associated with immune checkpoint inhibitors in an Asian population.

Methods

We performed a retrospective, propensity score-matched cohort study at two tertiary referral centers in Taiwan. Immune checkpoint inhibitor users were matched with non-immune checkpoint inhibitor users based on predetermined clinical variables. The primary outcome was major adverse cardiovascular events, defined as a composite of myocardial infarction, ischemic stroke, acute peripheral occlusive disease, pulmonary embolism, deep venous thromb

SUBMITTER: Chiang CH 

PROVIDER: S-EPMC9721460 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature