Molecular Mechanism of the Saposhnikovia divaricata-Angelica dahurica Herb Pair in Migraine Therapy Based on Network Pharmacology and Molecular Docking.

ABSTRACT:

Objective

This work studied the molecular mechanism of the Saposhnikovia divaricata-Angelica dahurica herb pair (SAHP) in migraine treatment.

Methods

The active ingredients of drugs were screened, and potential targets were predicted by the Traditional Chinese Medicine Systems Pharmacology (TCMSP), TCMID, ETCM, and other databases. Migraine-related targets were obtained by harnessing the GeneCards, DrugBank, OMIM, TTD, and other databases. The protein-protein interaction (PPI) network was constructed with STRING software by performing a Venn analysis with bioinformatics. Gene Ontology (GO) functional enrichment and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed with the Metascape platform. The component-target-pathway (C-T-P)

SUBMITTER: Wu F 

PROVIDER: S-EPMC9722292 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature