High-Resolution Views and Transport Mechanisms of the NKCC1 and KCC Transporters.

ABSTRACT: Cation-chloride cotransporters (CCCs) are responsible for the coupled co-transport of Cl^- with K⁺ and/or Na⁺ in an electroneutral manner. They play important roles in myriad fundamental physiological processes--from cell volume regulation to transepithelial solute transport and intracellular ion homeostasis--and are targeted by medicines commonly prescribed to treat hypertension and edema. After several decades of studies into the functions and pharmacology of these transporters, there have been several breakthroughs in the structural determination of CCC transporters. The insights provided by these new structures for the Na⁺/K⁺/Cl^- cotransporter NKCC1 and the K⁺/Cl^- cotransporters KCC1, KCC2, KCC3 and

SUBMITTER: Chew TA 

PROVIDER: S-EPMC9722358 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature