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Molecular docking analysis of flavonoids with aldose reductase.

ABSTRACT: Diabetes mellitus is a group of metabolic disorders that has risen to become the third most common cause in humans in recent years. The development of new bioactive substances from natural sources is a relatively new area. Flavonoids are believed to have a variety of beneficial properties in nature, including anti-inflammatory, antimicrobial, anticancer, antioxidant, neuroprotective, and anti-HIV properties. 15 naturally occurring flavonoids docked with the selected target aldose reductase. We report the optimal binding of Acumitin, Agathisflavone, Agehoustin B, and alpha-Toxicarol with aldose reductase for further consideration in drug discovery for T2DM.

SUBMITTER: Kannayiram K

PROVIDER: S-EPMC9722430 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Molecular docking analysis of flavonoids with aldose reductase.

Kannayiram Kasthuri K Umapathy Vidhya Rekha VR Chamundeswari Y Y Fathima J H JH Govindan Ramajayam R Palanisamy Chella Perumal CP Veeraraghavan Vishnu Priya VP Jayaraman Selvaraj S Rajagopal Ponnulakshmi P

Bioinformation 20220331 3

Diabetes mellitus is a group of metabolic disorders that has risen to become the third most common cause in humans in recent years. The development of new bioactive substances from natural sources is a relatively new area. Flavonoids are believed to have a variety of beneficial properties in nature, including anti-inflammatory, antimicrobial, anticancer, antioxidant, neuroprotective, and anti-HIV properties. 15 naturally occurring flavonoids docked with the selected target aldose reductase. We r ...[more]

PMID: 36518142

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