Differential symptom cluster responses to repetitive transcranial magnetic stimulation treatment in depression.

ABSTRACT:

Background

Repetitive transcranial magnetic stimulation (rTMS) can target specific neural circuits, which may allow for personalized treatment of depression. Treatment outcome is typically determined using sum scores from validated measurement scales; however, this may obscure differential improvements within distinct symptom domains. The objectives for this work were to determine: (1) whether a standard depression measure can be represented using a four symptom cluster model and (2) whether these symptom clusters had a differential response to rTMS treatment.

Methods

Data were obtained from two multi-centre randomized controlled trials of rTMS delivered to the left dorsolateral prefrontal cortex (DLPFC) for participants with treatment-resistant depression (TRD) conducted in

SUBMITTER: Kaster TS 

PROVIDER: S-EPMC9722479 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature