Open-source perfusion system for medium-scale fabrication of demineralized bone matrix chip grafts.

ABSTRACT: Demineralized bone matrix (DBM) is considered one of the most reliable bone tissue grafts for regular surgical use, as it provides a scaffold that is structurally like native bone, and that enhances bone regeneration. However, commercially available DBM products are not suited for surgical restitutions of large bones. Therefore, each Tissue Bank is urged to implement their own demineralization protocol, which usually does not meet the high demand for bone grafting. In this project, we developed an open source system for medium-scale manufacturing of DBM grafts from human cadaveric donors to automate the demineralization protocol and improve its reproducibility. The device consists in (1) unidirectional flow reaction chamber, where the demineralization protocol takes place; (2) automated sy

SUBMITTER: Jaramillo-Canas W 

PROVIDER: S-EPMC9722481 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature