Validation of a Computational Phenotype to Identify Acute Brain Dysfunction in Pediatric Sepsis.

ABSTRACT:

Objectives

To validate a computational phenotype that identifies acute brain dysfunction (ABD) based on clinician concern for neurologic or behavioral changes in pediatric sepsis.

Design

Retrospective observational study.

Setting

Single academic children's hospital.

Patients

Four thousand two hundred eighty-nine index sepsis episodes.

Interventions

None.

Measurements and main results

An existing computational phenotype of ABD was optimized to include routinely collected variables indicative of clinician concern for acute neurologic or behavioral change (completion of CT or MRI, electroencephalogram, or new antipsychotic administration). First, the computational phenotype was compared with an ABD reference standard established from chart review of

SUBMITTER: Alcamo AM 

PROVIDER: S-EPMC9722537 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature