Derivation and Validation of Vasoactive Inotrope Score Trajectory Groups in Critically Ill Children With Shock.

ABSTRACT:

Objectives

To determine whether there are clinically relevant and reproducible Vasoactive Inotrope Score (VIS) trajectories in children with shock during the acute phase of critical illness.

Design

Retrospective, observational cohort study.

Setting

Two tertiary, academic PICUs.

Patients

Children (< 18 yr old) who required vasoactive infusions within 24 hours of admission to the PICU. Those admitted post cardiac surgery were excluded.

Interventions

None.

Measurements and main results

An hourly VIS was calculated for the first 72 hours after initiation of vasoactives. Group-based trajectory modeling (GBTM) was applied to a derivation set (75% of encounters) and compared with the trajectories in a validation set (25% of encounters) using the same var

SUBMITTER: Perizes EN 

PROVIDER: S-EPMC9722555 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature