Mortality Risk in Pediatric Sepsis Based on C-reactive Protein and Ferritin Levels.

ABSTRACT:

Objectives

Interest in using bedside C-reactive protein (CRP) and ferritin levels to identify patients with hyperinflammatory sepsis who might benefit from anti-inflammatory therapies has piqued with the COVID-19 pandemic experience. Our first objective was to identify patterns in CRP and ferritin trajectory among critically ill pediatric sepsis patients. We then examined the association between these different groups of patients in their inflammatory cytokine responses, systemic inflammation, and mortality risks.

Data sources

A prospective, observational cohort study.

Study selection

Children with sepsis and organ failure in nine pediatric intensive care units in the United States.

Data extraction

Two hundred and fifty-five children were enrolled. Five distinc

SUBMITTER: Horvat CM 

PROVIDER: S-EPMC9722561 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature