Physical Activity Associates With Lower Systemic Inflammatory Gene Expression in Rheumatoid Arthritis.

ABSTRACT:

Objective

While general population studies have shown inverse associations between physical activity and common inflammatory biomarkers, the effects of physical activity on inflammatory gene expression and signaling pathways in rheumatoid arthritis (RA) remain unknown. We aimed to determine whether physical activity independently associates with expression of inflammatory genes among people with RA.

Methods

This was a prospective observational study of adults with RA. Physical activity was measured by quantitative actigraphy over 7 consecutive days, and peripheral blood collected during the same time period was used for RNA sequencing followed by differential gene expression, pathway, and network analyses.

Results

Actigraphy and RNA sequencing data were evaluated in 3

SUBMITTER: Patterson SL 

PROVIDER: S-EPMC9722583 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature