Adipose tissue radiodensity and mortality among patients with nonmetastatic breast cancer.

ABSTRACT:

Background & aims

Computed tomography (CT) scans can measure quantity and distribution of adipose tissue, which are associated with breast cancer prognosis. As a novel prognostic marker, radiodensity of adipose tissue has been examined in multiple cancer types, but never in breast cancer. Lower density indicates larger adipocytes with greater lipid content, whereas higher density can reflect inflammation, fibrosis, vascularity, or even metabolic changes; and both may impact breast cancer prognosis.

Methods

We included 2868 nonmetastatic patients with breast cancer diagnosed between January 2005 and December 2013 at Kaiser Permanente Northern California, an integrated healthcare system. From CT scans at diagnosis, we assessed the radiodensity of subcutaneous (SAT) and viscera

SUBMITTER: Cheng E 

PROVIDER: S-EPMC9722634 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature