[Comparative severity of COVID-19 cases caused by Alpha, Delta or Omicron SARS-CoV-2 variants and its association with vaccination].

ABSTRACT:

Background

This study compares the severity of SARS-CoV-2 infections caused by Alpha, Delta or Omicron variants in periods of co-circulation in Spain, and estimates the variant-specific association of vaccination with severe disease.

Methods

SARS-CoV-2 infections notified to the national epidemiological surveillance network with information on genetic variant and vaccination status were considered cases if they required hospitalisation or controls otherwise. Alpha and Delta were compared during June-July 2021; and Delta and Omicron during December 2021-January 2022. Adjusted Odds Ratios (aOR) were estimated using logistic regression, comparing variant and vaccination status between cases and controls.

Results

We included 5,345 Alpha and 11,974 Delta infections in June

SUBMITTER: Varea-Jimenez E 

PROVIDER: S-EPMC9722675 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature