Protein phosphatases regulate the liver microenvironment in the development of hepatocellular carcinoma.

ABSTRACT: The liver is a complicated heterogeneous organ composed of different cells. Parenchymal cells called hepatocytes and various nonparenchymal cells, including immune cells and stromal cells, are distributed in liver lobules with hepatic architecture. They interact with each other to compose the liver microenvironment and determine its characteristics. Although the liver microenvironment maintains liver homeostasis and function under healthy conditions, it also shows proinflammatory and profibrogenic characteristics that can induce the progression of hepatitis and hepatic fibrosis, eventually changing to a protumoral microenvironment that contributes to the development of hepatocellular carcinoma (HCC). According to recent studies, phosphatases are involved in liver diseases and HCC developme

SUBMITTER: Yoon JS 

PROVIDER: S-EPMC9722691 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature