Gypenosides ameliorate ductular reaction and liver fibrosis via inhibition of hedgehog signaling.

ABSTRACT: Backgroud and aims: Ductular reaction (DR) is a common pathological change and thought to have a key role in the pathogenesis and progression of liver fibrosis. Our previous study reported Gypenosides (GPs) ameliorated liver fibrosis, however, the anti-fibrotic mechanisms of GPs are still unclear. Methods: Liver fibrosis was induced in rats by carbon tetrachloride combining with 2-acerylaminofluorene (CCl₄/2-AAF), and Mdr2 knockout (Mdr2 ^-/-) mice to evaluate the anti-fibrotic role of GPs. In vitro, WB-F344 cells, a hepatic progenitor cells (HPCs) line, with or without Gli1 overexpressing lentiviral vectors, were induced by sodium butyrate (SB) to validate the mechanism of GPs and NPLC0393, the main ingredient of GPs. Results: Both i

SUBMITTER: Hu Y 

PROVIDER: S-EPMC9722742 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature