Preoperative plasma visfatin may have a dual effect on the occurrence of postoperative delirium.

ABSTRACT:

Background

Visfatin is considered to be a "novel pro-inflammatory cytokine." Neuroinflammatory response is one of the important mechanisms of postoperative delirium (POD). The relationship between preoperative plasma visfatin and POD is unclear.

Objective

To investigate the relationship between preoperative plasma visfatin concentrations and POD (primary outcome) in older hip fracture patients and to explore whether it affects POD through inflammatory factors.

Materials and methods

This prospective cohort study enrolled 176 elderly patients who were scheduled for hip fracture surgery. Preoperative plasma was collected on the morning of surgery, and visfatin levels were measured. Interleukin (IL)-1 and IL-6 were measured using patients' plasma collected on the first da

SUBMITTER: Kang N 

PROVIDER: S-EPMC9722954 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature