Lower insulin level is associated with sarcopenia in community-dwelling frail and non-frail older adults.

ABSTRACT:

Background

Sarcopenia is common among older individuals with and without type 2 diabetes mellitus (T2DM). There are conflicting evidence in support of the role of insulin in the development of age-related and T2DM-related sarcopenia. We investigated the relationships between the levels of fasting insulin and other blood biomarkers related to insulin or lipid metabolism with the presence of sarcopenia in two independent studies.

Materials and methods

In 246 pre-frail frail older individuals with (n = 41) and without T2DM (n = 205) in the Singapore Frailty Interventional Trial, sarcopenia was defined by low appendicular lean mass (ALM) relative to total body mass (skeletal muscle index, SMI = ALM/height²) and low lower limb strength or gait speed accor

SUBMITTER: Lu Y 

PROVIDER: S-EPMC9722960 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature