Project description:NK cells are believed to be involved in the immune pathogenesis of SAA. We used single cell RNA sequencing (scRNA-seq) to analyze the differences of NK cells in BM and PB between SAA patients and healthy volunteers.
Project description:Single Cell CNV experiment was performed in severe aplastic anaemia patients with known chromosome 7 abnormality. The goal of this project is to use single cell CNV to assess whether these abnormalities existed prior to immunosuppressive treatment (baseline) and were just too small to detect it with standard cytogenetics.