Novel Clinical Trial Designs in Neuro-Oncology.

ABSTRACT: Scientific and technologic advances have led to a boon of candidate therapeutics for patients with malignancies of the central nervous system. The path from drug development to clinical use has generally followed a regimented order of sequential clinical trial phases. The recent increase in novel therapies, however, has strained the regulatory process and unearthed limitations of the current system, including significant cost, prolonged development time, and difficulties in testing therapies for rarer tumors. Novel clinical trial designs have emerged to increase efficiencies in clinical trial conduct to better evaluate and bring impactful drugs to patients in a timely manner. In order to better capture meaningful benefits for brain tumor patients, new endpoints to complement or replace tra

SUBMITTER: Saraf A 

PROVIDER: S-EPMC9723049 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature