Toxicology assessment of manganese oxide nanomaterials with enhanced electrochemical properties using human in vitro models representing different exposure routes.

ABSTRACT: In the present study, a comparative human toxicity assessment between newly developed Mn₃O₄ nanoparticles with enhanced electrochemical properties (GNA35) and their precursor material (Mn₃O₄) was performed, employing different in vitro cellular models representing main exposure routes (inhalation, intestinal and dermal contact), namely the human alveolar carcinoma epithelial cell line (A549), the human colorectal adenocarcinoma cell line (HT29), and the reconstructed 3D human epidermal model EpiDerm. The obtained results showed that Mn₃O₄ and GNA35 harbour similar morphological characteristics, whereas differences were observed in relation to their surface area and electrochemical properties. In regard to their toxicological

SUBMITTER: Fernandez-Pampin N 

PROVIDER: S-EPMC9723098 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature