Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.

ABSTRACT: Pathological and genomic profiling have transformed breast cancer care by matching patients to targeted treatments. However, tumors evolve and evade therapeutic interventions often through the acquisition of genomic mutations. Here we examine patients profiled with tissue (TBx) and liquid biopsy (LBx) as part of routine clinical care, to characterize the tumor evolutionary landscape and identify potential vulnerabilities in the relapsed setting. Real-world evidence demonstrates that LBx is utilized later in care and identifies associations with intervening therapy. While driver events are frequently shared, acquired LBx alterations are detected in a majority of patients, with the highest frequency in ER+ disease and in patients with longer biopsy intervals. Acquired mutations are often pol

SUBMITTER: Sivakumar S 

PROVIDER: S-EPMC9723105 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature