The mitochondrial unfolded protein response (UPR^mt) protects against osteoarthritis.

ABSTRACT: The mitochondrial unfolded protein response (UPR^mt) is a mitochondrial-to-nuclear signaling pathway that is activated to maintain mitochondrial function when there is an accumulation of misfolded proteins within mitochondria. Mitochondrial function is essential for chondrocyte homeostasis, and mitochondrial dysfunction is a characteristic of osteoarthritis (OA). However, the role of the UPR^mt in OA remains unclear. In the present study, the level of the UPR^mt was examined in primary mouse chondrocytes subjected to different stresses and in the articular cartilage of OA model mice and OA patients. The relationship between UPR^mt activation and OA progression was studied. The UPR^mt was induced in primary mouse chondrocytes subjected to di

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC9723171 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature