Dataset Information

Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model.

ABSTRACT: Understanding how Baijiu facilitates blood circulation and prevents blood stasis is crucial for revealing the mechanism of Baijiu for cardiovascular disease (CVD) risk reduction. Here we established a zebrafish thrombosis model induced using arachidonic acid (AA) to quantitatively evaluate the antithrombotic effect of Wuliangye Baijiu. The prevention and reduction effects of aspirin, Wuliangye, and ethanol on thrombosis were compared using imaging and molecular characterization. Wuliangye Baijiu reduces thrombotic risks and oxidative stress in the AA-treated zebrafish, while ethanol with the same concentration has no similar effect. The prevention and reduction effects of Wuliangye on thrombosis are attributed to the change in the metabolic and signaling pathways related to platelet aggregation and adhesion, oxidative stress and inflammatory response.

SUBMITTER: Zhu H

PROVIDER: S-EPMC9723178 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model.

Zhu Hui H Lan Chaohua C Zhao Dong D Wang Ning N Du Di D Luo Huibo H Lu Huiqiang H Peng Zhifu Z Wang Yumeng Y Qiao Zongwei Z Huang Yong Y Sun Baoguo B

NPJ science of food 20221205 1

Understanding how Baijiu facilitates blood circulation and prevents blood stasis is crucial for revealing the mechanism of Baijiu for cardiovascular disease (CVD) risk reduction. Here we established a zebrafish thrombosis model induced using arachidonic acid (AA) to quantitatively evaluate the antithrombotic effect of Wuliangye Baijiu. The prevention and reduction effects of aspirin, Wuliangye, and ethanol on thrombosis were compared using imaging and molecular characterization. Wuliangye Baijiu ...[more]

PMID: 36470888

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Project description:BackgroundThe lifetime risks of cardiovascular disease have not been reported across the age spectrum in black adults and white adults.MethodsWe conducted a meta-analysis at the individual level using data from 18 cohort studies involving a total of 257,384 black men and women and white men and women whose risk factors for cardiovascular disease were measured at the ages of 45, 55, 65, and 75 years. Blood pressure, cholesterol level, smoking status, and diabetes status were used to stratify participants according to risk factors into five mutually exclusive categories. The remaining lifetime risks of cardiovascular events were estimated for participants in each category at each age, with death free of cardiovascular disease treated as a competing event.ResultsWe observed marked differences in the lifetime risks of cardiovascular disease across risk-factor strata. Among participants who were 55 years of age, those with an optimal risk-factor profile (total cholesterol level, <180 mg per deciliter [4.7 mmol per liter]; blood pressure, <120 mm Hg systolic and 80 mm Hg diastolic; nonsmoking status; and nondiabetic status) had substantially lower risks of death from cardiovascular disease through the age of 80 years than participants with two or more major risk factors (4.7% vs. 29.6% among men, 6.4% vs. 20.5% among women). Those with an optimal risk-factor profile also had lower lifetime risks of fatal coronary heart disease or nonfatal myocardial infarction (3.6% vs. 37.5% among men, <1% vs. 18.3% among women) and fatal or nonfatal stroke (2.3% vs. 8.3% among men, 5.3% vs. 10.7% among women). Similar trends within risk-factor strata were observed among blacks and whites and across diverse birth cohorts.ConclusionsDifferences in risk-factor burden translate into marked differences in the lifetime risk of cardiovascular disease, and these differences are consistent across race and birth cohorts. (Funded by the National Heart, Lung, and Blood Institute.).

Project description:Fetal alcohol spectrum disorders (FASD) are a group of physical, behavioral, and cognitive impairments caused by ethanol exposure during pregnancy. Zebrafish have emerged as a useful model for researching FASD and its variants in recent years. Oxidative stress has been identified as the primary damaging pathway, notwithstanding the possibility of other mechanisms at play. In this regard it's important to put an effort towards antioxidants which can exhibits and bare a potential to counteract the oxidative stress induced by ethanol during embryos development. Previosuly benzydamine has shown to protect macrophages against ethanol-induced condition by stabilizing redox homeostatis. This study aims to repurpose the Non-Steroidal Anti-Inflammatory Drug (NSAID) benzydamine to mitigate ethanol-induced teratogenesis during the early embryonic stage in Zebrafish. Zebrafish embryos were treated with 1% ethanol at 2 h post fertilization (hpf) and co-exposed with benzydamine (5-20 µM) after 2 h of ethanol treatment for 24 h. Reactive oxygen Species (ROS) and biochemical analysis was carried out at 48hpf. 1% ethanol significantly increased the production of ROS along with increased in lipid peroxidation followed by a decrease in glutathione (GSH) level when compoared to the control group (P < 0.001). These conditions were positively encountered by benzydamine (10, 15 µM) and returned to basal level. Involvement of two ethanol metabolizing enzymes cyp2y3 (Cytochrome P450, family 2, subfamily Y, polypeptide 3) and cyp3a65 Cytochrome P450, family 3, subfamily A, polypeptide 65 ) were also studied at 48hpf. 1% ethanol exposure aggregately elevated the expression of these two enzymes which showed a significant decrease in the benzydamine treated groups. Furthermore, the malformations and cellular damage due to 1% ethanol was studied at 96hpf, where 1% ethanol made severe malformation along with muscle fiber alteration, apoptosis in the brain and eye as manifested. These conditions were successfully reverted by benzydamine. In conclusion, ethanol causes oxidative stress, cellular damage along with severe malformation at early embryonic stage, which were partially prevented by the exposure of benzydamine.

Dataset Information

Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model.

Publications

Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model.

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