Effects of intestinal microbiota on pharmacokinetics of cyclosporine a in rats.

ABSTRACT:

Background

Intestinal microbiota has been confirmed to influencing the pharmacokinetic processes of a variety of oral drugs. However, the pharmacokinetic effects of the gut microbiota on cyclosporine A, a drug with a narrow therapeutic window, remain to be studied.

Method

Twenty-one rats were randomly divided into three groups: (a) control group (CON), (b) antibiotic treatment group (ABT) and (c) fecal microbe transplantation group (FMT). The ABT group was administrated with water containing multiple antibiotics to deplete microorganisms. FMT was with the same treatment, followed by oral administration of conventional rat fecal microorganisms for normalization.

Result

The bioavailability of CSA increased by 155.6% after intestinal microbes were consumed by antibiotics

SUBMITTER: Zhou J 

PROVIDER: S-EPMC9723225 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature