Comparison of detection methods and genome quality when quantifying nuclear mitochondrial insertions in vertebrate genomes.

ABSTRACT: The integration of mitochondrial genome fragments into the nuclear genome is well documented, and the transfer of these mitochondrial nuclear pseudogenes (numts) is thought to be an ongoing evolutionary process. With the increasing number of eukaryotic genomes available, genome-wide distributions of numts are often surveyed. However, inconsistencies in genome quality can reduce the accuracy of numt estimates, and methods used for identification can be complicated by the diverse sizes and ages of numts. Numts have been previously characterized in rodent genomes and it was postulated that they might be more prevalent in a group of voles with rapidly evolving karyotypes. Here, we examine 37 rodent genomes, and an additional 26 vertebrate genomes, while also considering numt detection methods.

SUBMITTER: Triant DA 

PROVIDER: S-EPMC9723244 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature