Novel insight of N⁶-methyladenosine modified subtypes in abdominal aortic aneurysm.

ABSTRACT: Background: N⁶-methyladenosine (m6A) is the most prevalent non-cap reversible modification present in messenger RNAs and long non-coding RNAs, and its dysregulation has been linked to multiple cardiovascular diseases, including cardiac hypertrophy and atherosclerosis. Although limited studies have suggested that m6A modification contributes to abdominal aortic aneurysm (AAA) development, the full landscape of m6A regulators that mediate modification patterns has not been revealed. Methods: To distinguish the m6A methylation subtypes in AAA patients, an unsupervised clustering method was carried out, based on the mRNA levels of 17 m6A methylation regulators. Differentially expressed genes were identified by comparing clusters. An m6Ascore model was calculated using

SUBMITTER: Wang K 

PROVIDER: S-EPMC9723249 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature