Modulation of Tumor-Treating Fields by Cerebral Edema from Brain Tumors.

ABSTRACT:

Purpose

Cerebral edema is an important component of brain metastasis, and its presence may alter the distribution of tumor-treating fields (TTFields). We therefore performed a computational study to model the extent of this alteration according to various edema conditions associated with the metastasis.

Methods and materials

Postacquisition magnetic resonance imaging data sets were obtained from 2 patients with solitary brain metastases from non-small cell lung cancer. After delineation of various anatomies, a 3-dimensional finite element mesh model was generated and then solved for the distribution of applied electric fields, rate of energy deposition, and current density at the gross tumor volume (GTV), edema, and other cranial structures. Electric field-volume histograms,

SUBMITTER: Lok E 

PROVIDER: S-EPMC9723310 | biostudies-literature | 2023 Jan-Feb

REPOSITORIES: biostudies-literature