Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic.

ABSTRACT: The Oxford Brain Health Clinic (BHC) is a joint clinical-research service that provides memory clinic patients and clinicians access to high-quality assessments not routinely available, including brain MRI aligned with the UK Biobank imaging study (UKB). In this work we present how we 1) adapted the UKB MRI acquisition protocol to be suitable for memory clinic patients, 2) modified the imaging analysis pipeline to extract measures that are in line with radiology reports and 3) explored the alignment of measures from BHC patients to the largest brain MRI study in the world (ultimately 100,000 participants). Adaptations of the UKB acquisition protocol for BHC patients include dividing the scan into core and optional sequences (i.e., additional imaging modalities) to improve patients' toleran

SUBMITTER: Griffanti L 

PROVIDER: S-EPMC9723313 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature