3T sodium MR imaging in Alzheimer's disease shows stage-dependent sodium increase influenced by age and local brain volume.

ABSTRACT:

Introduction

Application of MRI in clinical routine mainly addresses structural alterations. However, pathological changes at a cellular level are expected to precede the occurrence of brain atrophy clusters and of clinical symptoms. In this context, ²³Na-MRI examines sodium changes in the brain as a potential metabolic parameter. Recently, we have shown that ²³Na-MRI at ultra-high-field (7 T) was able to detect increased tissue sodium concentration (TSC) in Alzheimer's disease (AD). In this work, we aimed at assessing AD-pathology with ²³Na-MRI in a larger cohort and on a clinical 3T MR scanner.

Methods

We used a multimodal MRI protocol on 52 prodromal to mild AD patients and 34 cognitively healthy control subjects on a clinical 3T MR scanne

SUBMITTER: Haeger A 

PROVIDER: S-EPMC9723320 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature