Ontology highlight
ABSTRACT:
SUBMITTER: Kim HR
PROVIDER: S-EPMC9723350 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Kim Hyejeong Rosemary HR Warrington Samantha J SJ López-Guajardo Ana A Al Hennawi Khairat K Cook Sarah L SL Griffith Zak D J ZDJ Symmes Deebie D Zhang Tao T Qu Zhipeng Z Xu Ying Y Chen Ruihuan R Gad Annica K B AKB
Frontiers in cell and developmental biology 20221122
Metastasizing cells express the intermediate filament protein vimentin, which is used to diagnose invasive tumors in the clinic. However, the role of vimentin in cell motility, and if the assembly of non-filamentous variants of vimentin into filaments regulates cell migration remains unclear. We observed that the vimentin-targeting drug ALD-R491 increased the stability of vimentin filaments, by reducing filament assembly and/or disassembly. ALD-R491-treatment also resulted in more bundled and di ...[more]