Applying the concept of liquid biopsy to monitor the microbial biodiversity of marine coastal ecosystems.

ABSTRACT: Liquid biopsy (LB) is a concept that is rapidly gaining ground in the biomedical field. Its concept is largely based on the detection of circulating cell-free DNA (ccfDNA) fragments that are mostly released as small fragments following cell death in various tissues. A small percentage of these fragments are from foreign (nonself) tissues or organisms. In the present work, we applied this concept to mussels, a sentinel species known for its high filtration capacity of seawater. We exploited the capacity of mussels to be used as natural filters to capture environmental DNA fragments of different origins to provide information on the biodiversity of marine coastal ecosystems. Our results showed that hemolymph of mussels contains DNA fragments that varied considerably in size, ranging from 1 t

SUBMITTER: Ferchiou S 

PROVIDER: S-EPMC9723566 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature