Chromatin accessibility-based characterisation of brain gene regulatory networks in three distinct honey bee polyphenisms.

ABSTRACT: The honey bee genome has the capacity to produce three phenotypically distinct organisms (two diploid female castes: queen and worker, and a haploid male drone). Previous studies have implicated metabolic flux acting via epigenetic regulation in directing nutrition-driven phenotypic plasticity in the honey bee. However, the cis-acting DNA regulatory elements that establish tissue and polyphenism -specific epigenomes and gene expression programmes, remain unclear. Using a high resolution multiomic approach including assay for transposase-accessible chromatin by sequencing (ATAC-seq), RNA-seq and ChIP-seq, we produce the first genome-wide maps of the regulatory landscape across all three adult honey bee phenotypes identifying > 5000 regulatory regions in queen, 7500 in worker and 6500 in dro

SUBMITTER: Lowe R 

PROVIDER: S-EPMC9723623 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature