EIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells.

ABSTRACT: Increasing studies have revealed that a subset of circular RNAs (circRNAs) harbor an open reading frame and can act as protein-coding templates to generate functional proteins that are closely associated with multiple physiological and disease-relevant processes, and thus proper regulation of synthesis of these circRNA-derived proteins is a fundamental cellular process required for homeostasis maintenance. However, how circRNA translation initiation is coordinated by different trans-acting factors remains poorly understood. In particular, the impact of different eukaryotic translation initiation factors (eIFs) on circRNA translation and the physiological relevance of this distinct regulation have not yet been characterized. In this study, we screened all 43 Drosophila eIFs and revealed the

SUBMITTER: Song Z 

PROVIDER: S-EPMC9723666 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature