Relationship between bacterial phylotype and specialized metabolite production in the culturable microbiome of two freshwater sponges

ABSTRACT: Microbial drug discovery programs rely heavily on accessing bacterial diversity from the environment to acquire new specialized metabolite (SM) lead compounds for the therapeutic pipeline. Therefore, knowledge of how commonly culturable bacterial taxa are distributed in nature, in addition to the degree of variation of SM production within those taxa, is critical to informing these front-end discovery efforts and making the overall sample collection and bacterial library creation process more efficient. In the current study, we employed MALDI-TOF mass spectrometry and the bioinformatics pipeline IDBac to analyze diversity within phylotype groupings and SM profiles of hundreds of bacterial isolates from two Eunapius fragilis freshwater sponges, collected 1.5 km apart. We demonstrated that w

SUBMITTER: Clark C 

PROVIDER: S-EPMC9723699 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature