Transcriptome architecture and regulation at environmental transitions in flavobacteria: the case of an important fish pathogen.

ABSTRACT: The family Flavobacteriaceae (phylum Bacteroidetes) is a major component of soil, marine and freshwater ecosystems. In this understudied family, Flavobacterium psychrophilum is a freshwater pathogen that infects salmonid fish worldwide, with critical environmental and economic impact. Here, we report an extensive transcriptome analysis that established the genome map of transcription start sites and transcribed regions, predicted alternative sigma factor regulons and regulatory RNAs, and documented gene expression profiles across 32 biological conditions mimicking the pathogen life cycle. The results link genes to environmental conditions and phenotypic traits and provide insights into gene regulation, highlighting similarities with better known bacteria and original characteristics linked

SUBMITTER: Guerin C 

PROVIDER: S-EPMC9723704 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature