PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds.

ABSTRACT:

Objective

Skeletal muscle is a pivotal organ for the coordination of systemic metabolism, constituting one of the largest storage site for glucose, lipids and amino acids. Tight temporal orchestration of protein breakdown in times of fasting has to be balanced with preservation of muscle mass and function. However, the molecular mechanisms that control the fasting response in muscle are poorly understood.

Methods

We now have identified a role for the peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) in the regulation of catabolic pathways in this context in muscle-specific loss-of-function mouse models.

Results

Muscle-specific knockouts for PGC-1β experience mitigated muscle atrophy in fasting, linked to reduced expression of myostatin, atrogenes, a

SUBMITTER: Schmid S 

PROVIDER: S-EPMC9723918 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature