Mesenchymal stem cells-derived exosomal miR-653-5p suppresses laryngeal papilloma progression by inhibiting BZW2

ABSTRACT: Highlights • The downregulation of miR-653-5p is involved in the progression of LP.• MSCs-derived exosomal miR-653-5p suppressed the malignant behaviors of LP cells.• The role of MSCs-derived exosomal miR-653-5p in LP relied on BZW2.

Objectives

Although miR-653-5p has been validated to participate in the progression of multiple types of cancer, the functional role of exosomal miR-653-5p derived from Mesenchymal Stem Cells (MSCs) in Laryngeal Papilloma (LP) has still remained elusive. Hence, this study aimed to investigate the role of MSCs-derived exosomal miR-653-5p in LP.

Methods

LP tissues (n = 15) and adjacent normal tissues (n = 10) were collected to examine the expression level of miR-653-5p. The expression level of miR-653-5p in LP cells and normal cells was also de

SUBMITTER:  

PROVIDER: S-EPMC9723928 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature