MITF is a novel transcriptional regulator of the calcium sensor STIM1: Significance in physiological melanogenesis.

ABSTRACT: Stromal Interaction Molecule1 (STIM1) is an endoplasmic reticulum membrane-localized calcium (Ca²⁺) sensor that plays a critical role in the store-operated Ca²⁺ entry (SOCE) pathway. STIM1 regulates a variety of physiological processes and contributes to a plethora of pathophysiological conditions. Several disease states and enhanced biological phenomena are associated with increased STIM1 levels and activity. However, molecular mechanisms driving STIM1 expression remain largely unappreciated. We recently reported that STIM1 expression augments during pigmentation. Nonetheless, the molecular choreography regulating STIM1 expression in melanocytes is completely unexplored. Here, we characterized the molecular events that regulate STIM1 expression during pigmentation. W

SUBMITTER: Tanwar J 

PROVIDER: S-EPMC9723939 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature