The power of a healthy lifestyle for cancer prevention: the example of colorectal cancer.

ABSTRACT:

Objective

We aimed to directly compare the estimated effects of adherence to a healthy lifestyle with those of risk predisposition according to known genetic variants affecting colorectal cancer (CRC) risk, to support effective risk communication for cancer prevention.

Methods

A healthy lifestyle score (HLS) was derived from 5 lifestyle factors: smoking, alcohol consumption, diet, physical activity, and body adiposity. The association of lifestyle and polygenic risk score (PRS) (based on 140 CRC-associated risk loci) with CRC risk was assessed with multiple logistic regression and compared through the genetic risk equivalent (GRE), a novel approach providing an estimate of the effects of adherence to a healthy lifestyle in terms of percentile differences in PRS.

Results</

SUBMITTER: Chen X 

PROVIDER: S-EPMC9724224 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature