Dataset Information

The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study.

ABSTRACT:

Background

Most of hepatocellular carcinoma (HCC) arises on the background of chronic inflammation. The presence of infiltrating inflammatory cells is associated with tumour initiation, progression and clinical response to treatment. The influence of white blood cell (WBC) subtype counts on HCC progression remains unclear.

Methods

In this study, we performed a Mendelian randomization (MR) study with the validation of two datasets. The summary data for WBC counts were extracted from a recent large GWAS of individuals of European ancestry. The GWAS data related to HCC were obtained from the UK Biobank (UKB). Univariable and multivariable MR analyses were used to identify risk factors genetically associated with HCC risks.

Results

In the discovery dataset, multivariable MR analysis revealed that sum basophil neutrophil counts had an independent causal effect on the occurrence of HCC, with the sum basophil neutrophil counts as follows: (OR = 0.437, P = 0.003, CI 0.252-0.757). Similarly, in the validation dataset, total basophil neutrophil counts were also been identified as an independent risk factor for HCC. The sum basophil neutrophil counts were as follows: (OR = 0.574, P = 0.021, CI 0.358-0.920).

Conclusion

In the European population, genetically predicted lower total basophil neutrophil counts might be an independent risk factor for HCC.

SUBMITTER: Pan GQ

PROVIDER: S-EPMC9724280 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study.

Pan Guo-Qiang GQ Yang Chun-Cheng CC Shang Xiao-Ling XL Dong Zhao-Ru ZR Li Tao T

European journal of medical research 20221206 1

<h4>Background</h4>Most of hepatocellular carcinoma (HCC) arises on the background of chronic inflammation. The presence of infiltrating inflammatory cells is associated with tumour initiation, progression and clinical response to treatment. The influence of white blood cell (WBC) subtype counts on HCC progression remains unclear.<h4>Methods</h4>In this study, we performed a Mendelian randomization (MR) study with the validation of two datasets. The summary data for WBC counts were extracted fro ...[more]

PMID: 36471350

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Dataset Information

The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study.

Background

Methods

Results

Conclusion

Publications

The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study.

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