Dyslipidemia induced large-scale network connectivity abnormality facilitates cognitive decline in the Alzheimer's disease.

ABSTRACT:

Background

Although lipid metabolite dysfunction contributes substantially to clinical signs and pathophysiology of Alzheimer's disease (AD), how dyslipidemia promoting neuropathological processes and brain functional impairment subsequently facilitates the progression of AD remains unclear.

Methods

We combined large-scale brain resting-state networks (RSNs) approaches with canonical correlation analysis to explore the accumulating effects of lipid gene- and protein-centric levels on cerebrospinal fluid (CSF) biomarkers, dynamic trajectory of large-scale RSNs, and cognitive performance across entire AD spectrum. Support vector machine model was used to distinguish AD spectrum and pathway analysis was used to test the influences among these variables.

Results

We found

SUBMITTER: Wang Q 

PROVIDER: S-EPMC9724298 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature