Designing electrospun fiber platforms for efficient delivery of genetic material and genome editing tools.

ABSTRACT: Electrospun fibers are versatile biomaterial platforms with great potential to support regeneration. Electrospun fiber characteristics such as fiber diameter, degree of alignment, rate of degradation, and surface chemistry enable the creation of unique, tunable scaffolds for various drug or gene delivery applications. The delivery of genetic material and genome editing tools via viral and non-viral vectors are approaches to control cellular protein production. However, immunogenicity, off-target effects, and low delivery efficiencies slow the progression of gene delivery strategies to clinical settings. The delivery of genetic material from electrospun fibers overcomes such limitations by allowing for localized, tunable delivery of genetic material. However, the process of electrospinning

SUBMITTER: Puhl DL 

PROVIDER: S-EPMC9724629 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature