The Autophagy Receptor TAX1BP1 (T6BP) improves antigen presentation by MHC-II molecules.

ABSTRACT: CD4⁺ T lymphocytes play a major role in the establishment and maintenance of immunity. They are activated by antigenic peptides derived from extracellular or newly synthesized (endogenous) proteins presented by the MHC-II molecules. The pathways leading to endogenous MHC-II presentation remain poorly characterized. We demonstrate here that the autophagy receptor, T6BP, influences both autophagy-dependent and -independent endogenous presentation of HIV- and HCMV-derived peptides. By studying the immunopeptidome of MHC-II molecules, we show that T6BP affects both the quantity and quality of peptides presented. T6BP silencing induces the mislocalization of the MHC-II-loading compartments and rapid degradation of the invariant chain (CD74) without altering the expression and interna

SUBMITTER: Sarango G 

PROVIDER: S-EPMC9724678 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature