Depressive symptom trajectories and polygenic risk scores in individuals with an immune-mediated inflammatory disease.

ABSTRACT:

Objective

To develop group-based trajectories of depressive symptoms in immune-mediated inflammatory disease (IMID) to understand their evolution and identify any associated factors, with the overall goal of identifying those at highest risk of higher depressive symptom burden.

Method

922 participants had an IMID or anxiety/depression. The PHQ-9 was administered at four visits, and polygenic risk scores (PRS) for major depressive disorder, depressive symptoms, and body mass index (BMI) were generated. Group-based trajectory modelling of PHQ-9 scores estimated distinct trajectories. Regression tested whether specific factors were associated with the trajectories. Mediation analyses assessed whether IMID mediated the association between BMI PRS and trajectories.

Results

SUBMITTER: Kowalec K 

PROVIDER: S-EPMC9724746 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature