Interictal epileptiform discharges show distinct spatiotemporal and morphological patterns across wake and sleep.

ABSTRACT: Presurgical evaluation of mesial temporal and neocortical focal pharmacoresistant epilepsy patients using intracranial EEG recordings has led to the generation of extensive data on interictal epileptiform discharges, located within or remotely from seizure onset zones. In this study, we used this data to investigate how interictal epileptiform discharges are modulated and how their spatial distribution changes during wake and sleep and analysed the relationship between these discharge events and seizure onset zones. Preoperative evaluation data from 11 adult patients with focal pharmacoresistant epilepsy were extracted from the Epilepsiae database. Interictal epileptiform discharges were automatically detected during wakefulness and over several hours of continuous seizure-free sleep (tota

SUBMITTER: Fouad A 

PROVIDER: S-EPMC9724782 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature