Therapeutic efficacy of n-Docosanol against velogenic Newcastle disease virus infection in domestic chickens.

ABSTRACT:

Introduction

The control of Newcastle disease virus (NDV) infection depends solely on vaccination which in most cases is not sufficient to restrain the consequences of such a highly evolving viral disease. Finding out substances for preparing an efficient anti-ND drug would be of high value. n-Docosanol is a saturated fatty alcohol with an inhibitory effect against many enveloped viruses. In this study, we evaluated the therapeutic effect of n-docosanol on NDV infection and shedding in chickens.

Methods

Chickens infected with a highly virulent NDV were treated with low to high concentrations of n-docosanol (20, 40, and 60 mg/kg body weight) for 4-successive days, once they showed the disease symptoms. Survival and curative rates, virus load, histopatholo

SUBMITTER: Orabi A 

PROVIDER: S-EPMC9724783 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature