Shared genetic mechanism between type 2 diabetes and COVID-19 using pathway-based association analysis.

ABSTRACT: Recent studies have shown that, compared with healthy individuals, patients with type 2 diabetes (T2D) suffer a higher severity and mortality of COVID-19. When infected with this retrovirus, patients with T2D are more likely to face severe complications from cytokine storms and be admitted to high-dependency or intensive care units. Some COVID-19 patients are known to suffer from various forms of acute respiratory distress syndrome and have a higher mortality risk due to extreme activation of inflammatory cascades. Using a conditional false discovery rate statistical framework, an independent genome-wide association study data on individuals presenting with T2D (N = 62,892) and COVID-19 (N = 38,984) were analysed. Genome-wide association study data from 2,343,084 participants were a

SUBMITTER: Wu KCH 

PROVIDER: S-EPMC9724785 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature