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ABSTRACT: Despite historical controversy, pharmacologic ascorbate is emerging as promising cancer therapy via pro-oxidant chemistry. In this issue of Cancer Cell, Schoenfeld et al. describe how intracellular iron pools and reactive oxygen species drive pharmacologic ascorbate's selective toxicity to cancer cells in vitro, in mice, and in humans.

SUBMITTER: Levine M 

PROVIDER: S-EPMC9724800 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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