National French registry of spontaneous coronary artery dissections: prevalence of fibromuscular dysplasia and genetic analyses.

ABSTRACT:

Background

Spontaneous coronary artery dissection (SCAD) is an increasingly reported but poorly understood condition. Few European data are available.

Aims

The aims of this study were to obtain European data on SCAD, determine the prevalence of fibromuscular dysplasia (FMD) and enable genetic analyses in this population.

Methods

Data from a national French registry of SCAD cases were analysed prospectively and retrospectively. Clinical and angiographic data and management strategy were collected. Major adverse cardiovascular events (MACE) were analysed after one year of follow-up. Subjects were screened for FMD and blood was collected for DNA extraction.

Results

From June 2016 to August 2018, 373 SCAD cases were confirmed by the core lab. Mean age was 51.5 year

SUBMITTER: Combaret N 

PROVIDER: S-EPMC9725012 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature