Culprit lesion location and outcomes in patients with multivessel disease and infarct-related cardiogenic shock: a core laboratory analysis of the CULPRIT-SHOCK trial.

ABSTRACT:

Background

Critical culprit lesion locations (CCLL) such as left main (LM) and proximal left anterior descending (LAD) are associated with worse clinical outcome in myocardial infarction without cardiogenic shock (CS).

Aims

We aimed to assess whether CCLL identify a subgroup of patients with poorer prognosis when presenting with CS.

Methods

In the CULPRIT-SHOCK trial, a core laboratory reviewed all coronary angiograms to identify CCLL. A CCLL was defined as a culprit lesion with a >70% diameter stenosis of the LM, LM equivalent (>70% diameter stenosis of both proximal LAD and proximal circumflex), proximal LAD or last remaining vessel. We evaluated the primary study endpoint of the CULPRIT-SHOCK trial according to CCLL.

Results

A total of 269 (43%) out of 626 p

SUBMITTER: Hauguel-Moreau M 

PROVIDER: S-EPMC9725066 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature