Comparison of acute thrombogenicity and albumin adsorption in three different durable polymer coronary drug-eluting stents.

ABSTRACT:

Background

The relative thrombogenicity and albumin adsorption and retention of different durable polymers used in coronary stents has not been tested.

Aims

This study sought to compare the thromboresistance and albumin binding capacity of different durable polymer drug-eluting stents (DES) using dedicated preclinical and in vitro models.

Methods

In an ex vivo swine arteriovenous shunt model, a fluoropolymer everolimus-eluting stent (FP-EES) (n=14) was compared with two durable polymer DES, the BioLinx polymer-coated zotarolimus-eluting stent (BL-ZES) (n=9) and a CarboSil elastomer polymer-coated ridaforolimus-eluting stent (EP-RES) (n=6), and bare metal stents (BMS) (n=10). Stents underwent immunostaining using a cocktail of antiplatelet antibodies and a marker for i

SUBMITTER: Jinnouchi H 

PROVIDER: S-EPMC9725074 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature